Swedish diabetes patients' experiences of using GLP-1 - DiVA

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Feature Article / Incretin-Related Therapies in Type 2 Diabetes Abstract. Address correspondence to Carolyn Robertson, APRN, MSN, ACNS-BC, BC-ADM, CDE, UCLA Gonda Diabetes Center, 200 UCLA Medical Plaza, Suite 530, Los Angeles, CA 90025. Incretin-Related Therapies in Type 2 Diabetes: A Practical Diabetes, Obesity and Metabolism. Volume 22, Issue 8 p. 1328-1338. ORIGINAL ARTICLE. Incretin combination therapy for the treatment of non‐alcoholic steatohepatitis.

Both classes of drug can, in principle, successfully be used in drug-naïve patients, but the official indications are patients are being treated with one or more oral antidiabetic agent. Whilst metformin remains the first-line therapy option for patient with type 2 diabetes, modulation of incretin activity, through addition of a GLP-1 receptor agonist or a DPP-4 inhibitor, represents a potential second-line therapy option for patients failing to achieve glycemic control on metformin monotherapy. This therapy works by slowing gastric emptying and suppressing inappropriately elevated glucagon levels. These affects can cause weight loss in many patients.6,8 Weight loss can average 5.4 kg at Incretin-based therapies, either incretin enhancers (eg, dipeptidyl peptidase-4 [DPP-4] inhibitors such as gliptins) or incretin mimetics (eg, glucagon-like peptide-1 [GLP-1] receptor agonists) are increasingly used for treatment of type 2 diabetes mellitus, because of their good glucose-lowering activity without induction of hypoglycaemia or weight gain.1 DPP-4 inhibitors and GLP-1 receptor agonists are, among other pharmacological options, second-line treatments after failure of metformin Incretin-Based Therapies in Type 2 Diabetes Mellitus Chee W. Chia and Josephine M. Egan National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224-6825 Exenatide is the first incretin-related therapy available for patients with type 2 diabetes.

Together, obesity and diabetes form a 21st century epidemic, the treatment of which consumes a substantial fraction of global health costs. New and improved The aim of the present study was to examine the effects of incretin-based therapy on cognitive performance in type 2 diabetes patients DPP-4 Inhibition Islet- and Incretin Hormones in Health and Type 2 Diabetes Glucagon Counter-Regulation to Hypoglycemia During Incretin-Based Therapy. Type 2 diabetes is one of the leading causes of morbidity and mortality.

MOLECULAR REGULATION OF HORMONE SECRETION

Mar;3(3):153-65. Review. 7.

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• Has an approximate 50% amino acid homology with GLP-1. • Binds to GLP-1 receptors and behaves as GLP-1.

Incretin-based therapies are not without controversy, though. 2018-02-01 · Incretin-based therapy for the treatment of bone fragility in diabetes mellitus Author links open overlay panel Guillaume Mabilleau a b c Benoît Gobron a d Béatrice Bouvard a d Daniel Chappard a b c Diabetes Spectrum. Volume 24, Number 1, 2011. Feature Article / Incretin-Related Therapies in Type 2 Diabetes Abstract. Address correspondence to Carolyn Robertson, APRN, MSN, ACNS-BC, BC-ADM, CDE, UCLA Gonda Diabetes Center, 200 UCLA Medical Plaza, Suite 530, Los Angeles, CA 90025.
Rimlexikon

Nyckelord :diabetes typ 2; nutritionsbehandling; vegan; växtbaserad; vegankost; GLP-1; inkretiner; postprandiellt.; type 2 diabetes; nutritional therapy; vegan; new inroads into prevention and treatment of type 2 diabetes.

There is a reduction of the incretin effect in individuals with type 2 diabetes, which can be rectified through the administration of exogenous native GLP-1. 3,4 Hence, continuous intravenous infusion of GLP-1 in subjects with type 2 diabetes increases insulin secretion, reduces glucagon secretion, and lowers plasma glucose. 5 The effect of GLP-1 is glucose-dependent, so despite ongoing Incretin Replacement Therapy: A New Treatment Tool for Type 2 Diabetes.
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Handbook of Incretin-based Th... - LIBRIS

Author information: (1)Diabetes Research Institute, Mills-Peninsula Health Services, San Mateo, CA 94401, USA. dklonoff@yahoo.com Treatment with GLP-1 receptor agonists (“incretin mimetics”) and DPP-4 inhibitors (“incretin enhancers”) are based on antidiabetic properties of insulinotropic gut hormones (“incretins”). Although they represent different approaches to therapy in patients with type 2 diabetes, there are notable similarities (Table 1).

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Handbook of Incretin-Based Therapies in Type 2 Diabetes: Gough

Improved understanding of the physiology underlying incretins has led to the development of new therapies that act through modulation of the incretin system. These agents offer some potential advantages over previous antidiabetes drugs and have been approved for use Recently, incretin-based therapeutic agents, such as glucagon-like peptide-1 and dipeptidyl peptidase-4 inhibitors, have been reported to elicit vasotropic actions, suggesting a potential for effecting an actual reduction in diabetic vascular complications. Umpierrez GE, Korytkowski M. Is incretin-based therapy ready for the care of hospitalized patients with type 2 diabetes?: Insulin therapy has proven itself and is considered the mainstay of treatment. Diabetes Care. 2013;36:2112–7. PubMed Central PubMed Article Google Scholar 2018-07-16 · Due to the conflicting results, we collected all the available data and conducted a meta-analysis to robustly evaluate the influence of incretin-based therapy added to insulin vs placebo or no drug added to insulin in subjects with type 1 diabetes on the key outcomes HbA1c, total insulin dose, body weight, severe hypoglycaemia and gastrointestinal side effects.

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developed to treat type 2 diabetes hold promise. as a novel The type 2 diabetes-associated gene ide is required for insulin secretion Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion. mechanisms and implications for therapy. Vassleprotein Whey mot fetma och Diabetes typ 2 Nauck MA, Vilsboll T, Gallwitz B, Garber A, Madsbad S. Incretin-based therapies: Micronised Resveratrol as a Treatment for Friedreich Ataxia disorder characterized by ataxia, dysarthria, sensory loss, diabetes and Treatment of Wolfram Syndrome Type 2 With the Chelator Deferiprone and Incretin Based Therapy. Drucker D J. The biology of incretin hormones. Cell Metab. 2006.

Whilst metformin remains the first-line therapy option for patient with type 2 diabetes, modulation of incretin activity, through addition of a GLP-1 receptor agonist or a DPP-4 inhibitor, represents a potential second-line therapy option for patients failing to achieve glycemic control on metformin monotherapy. This therapy works by slowing gastric emptying and suppressing inappropriately elevated glucagon levels.